A lifestyle that involves the regular intake of low-fat vegetarian diets, aerobic exercise, and stress reduction may improve and reverse the conditions of coronary heart disease patients.
Trimethylamine-N-oxide (TMAO), a metabolite produced by intestinal microbes, is associated with elevated atherosclerosis and cardiovascular disease risk.
Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
High serum and urine concentrations of TMAO, produced from intestinal microbial metabolism of phosphatidylcholine, may increase an individual’s susceptibility to adverse cardiac events and cardiovascular diseases.
Supported by grants from the National Institutes of Health and its Office of Dietary Supplements (R01HL103866 and 1P20HL113452). The clinical study GeneBank was supported by grants from the National Institutes of Health (P01HL098055, P01HL076491, R01HL103931, and R01DK080732) and a Cleveland Clinic/Case Western Reserve University Clinical and Translational Science Award (UL1TR000439). Dr. Hazen was supported by a gift from the Leonard Krieger Fund. Mass spectrometry instrumentation used was housed within the Cleveland Clinic Mass Spectrometry Facility with partial support through a Center of Innovation by AB SCIEX.
Kent L, Morton D, Rankin P, Ward E, Grant R, Gobble J, Diehl H.
Avondale College of Higher Education, 582 Freemans Drive (PO BOX 19), Cooranbong NSW 2265, Australia Australasian Research Institute, 185 Fox Valley Rd, Wahroonga, NSW 2076, Australia Medical Nutrition Therapy Northwest, 13568 SE 97th Ave. Suite 203 Clackamas, Oregon 97015, USA Lifestyle Medicine Institute, PO Box 818, Loma Linda, CA 92354, USA
This study was supported by a Health Sciences Research Grant (Comprehensive Research on Diabetes/Cardiovascular and Life-Style Related Diseases H22-019) from the Ministry of Health, Labour and Welfare of Japan.
High intake of whole grains is associated with low serum concentrations of high sensitivity C-reactive protein and improved reproductive health in pre-menopausal women.
Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20852, USA.
Lagiou P, Sandin S, Lof M, Trichopoulos D, Adami HO, Weiderpass E.
Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75 M. Asias Street, Goudi, GR-115 27 Athens, Greece. pdlagiou@med.uoa.gr
Sodium consumption above 2g per day is one of the major causes of cardiovascular-related deaths worldwide. This study examined the effect of sodium consumption on global cardiovascular mortality. Researchers analyzed dietary and clinical data obtained from subjects in 66 countries. The blood pressure and cardiovascular mortality hazard ratios were assessed in all the subjects. Researchers...
Mozaffarian D, Fahimi S, Singh GM, Micha R, Khatibzadeh S, Engell RE, Lim S, Danaei G, Ezzati M, Powles J; Global Burden of Diseases Nutrition and Chronic Diseases Expert Group.
Mozaffarian D, Ezzati M, Fahimi S, Khatibzadeh S, Micha R, Powles J, Shi P, Elmadfa I, Kalantarian S, Rao M, Wirojratana P, Lim SS, Andrews KG, Engell RE, Elliott P, Brown I, Britton J, Fogarty A, Land MA, Lewis S, McKeever T, Neal B, Ocké MC, Webster J, Abbott PA, Abdollahi M, Gilardon EA, de Salud M, Ahsan H, Al Nsour MA, Al-Hooti SN, Barennes H, Barquera S, Baylin A, Becker W, Bjerregaard P, Bourne LT, Calleja N, Capanzana MV, Castetbon K, Chang HY, Chen Y, Cowan MJ, De Henauw S, Ding EL, Duante CA, Duran P, Elmadfa I, Barbieri HE, Farzadfar F, Fernando DN, Hadziomeragic AF, Fisberg RM, Forsyth SJ, Garriguet D, Gauci D, Ginnela BN, Guessous I, Gulliford MC, Hadden WC, Haerpfer C, Hoffman DJ, Houshiar-rad A, Huybrechts I, Hwalla NC, Ibrahim HM, Inoue M, Jackson MD, Johansson L, Keinan-Boker L, Kim CI, Koksal E, Li Y, Lipoeto NI, Ma G, Mangialavori GL, Matsumura Y, McGarvey ST, Fen CM, Mensink GB, Koch R, Monge-Rojas R, Musaiger AO, Naska A, Ocke MC, Oltarzewski M, Orfanos P, Ovaskainen ML, Pan WH, Panagiotakos DB, Pekcan GA, Petrova S, Piaseu N, Pitsavos C, Posada LG, Riley LM, Sánchez-Romero LM, Selamat RB, Sharma S, Sibai AM, Sichieri R, Simmala C, Steingrimsdottir L, Sygnowska EH, Szponar L, Tapanainen H, Templeton R, Thanopoulou A, Thorgeirsdóttir H, Thorsdottir I, Trichopoulou A, Tsugane S, Turrini A, Vaask S, Veerman JL, Verena N, Waskiewicz A, Zaghloul S, Zajkás G.
L-carnitine, a major component of red meat, may increase an individual’s susceptibility to cardiovascular disease, such as atherosclerosis, and adverse cardiac events, such as stroke and myocardial infarction.
Robert A. Koeth, Zeneng Wang,Bruce S. Levison, Jennifer A. Buffa, Elin Org, Brendan T. Sheehy, Earl B. Britt, Xiaoming Fu, Yuping Wu, Lin Li, Jonathan D. Smith, Joseph A. DiDonato, Jun Chen, Hongzhe Li, Gary D. Wu, James D. Lewis, Manya Warrier, J. Mark Brown, Ronald M. Krauss, W. H. Wilson Tang, Frederic D. Bushman, Aldons J. Lusis, and Stanley L. Hazen
Department of Cellular & Molecular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA Center for Cardiovascular Diagnostics and Prevention, Cleveland Clinic, Cleveland, Ohio 44195, USA Department of Medicine/Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles 90095, USA Department of Mathematics, Cleveland State University, Cleveland, Ohio 44115, USA Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio 44195, USA Department of Microbiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA Department of Pathology, Section on Lipid Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA Children’s Hospital Oakland Research Institute, Oakland, CA 94609, USA Address for Correspondence: Stanley L. Hazen, MD PhD, Department of Cellular & Molecular Medicine, Cleveland Clinic, 9500 Euclid Avenue, NC-10, Cleveland, OH 44195, Phone: (216) 445-9763, Fax: (216) 636-0392, Email: gro.fcc@snezah
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