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Associations between dietary folate intake and risks of esophageal, gastric and pancreatic cancers: an overall and dose-response meta-analysis.

​Adequate intake of foods rich in folate may help to inhibit the development of cancerous cells in the esophagus, stomach, and pancreas.

The objective of this study was to conduct a meta-analysis on the association between regular dietary ingestion of foods high in folate and the likelihood of developing stomach (gastric), esophageal, and pancreatic cancer. A group of scientists reviewed data obtained from a total of 46 studies that analyzed this association.

The research team observed a low incidence of esophageal, pancreatic, and stomach cancer in individuals who consistently consumed diets rich in folate-containing foods. Regular dietary intake of an extra 100 micrograms of folate per day was found to cut down the risk of developing pancreatic, stomach, and esophageal cancer by 6%, 1.5%, and 9% respectively in this study. The results of this study suggest that a decline in esophageal, stomach, and pancreatic cancer risk is associated with increased consumption of foods loaded with folate.

Research Summary Information

  • 2017
  • Liu W, Zhou H, Zhu Y, Tie C.
  • Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, P. R. China. Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, Hubei Province, P. R. China. Department of Stomatology, Taikang Tongji Hospital, Wuhan, 430000, Hubei Province, P. R. China.
  • Yes, Free full text of study was found:
  • No. Source of funding disclosure not found
  • No. Potential conflicts disclosure not found
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