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Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies.

​The odds of preventing breast cancer may be stacked in favor of women with high circulating levels of carotenoids, such as of α-carotene, β-carotene, lutein, zeaxanthin, and lycopene.

This study assessed how plasma concentrations of carotenoids, such as carotene, β-carotene, lutein, zeaxanthin, β-Cryptoxanthin, and lycopene, affect the risk of developing breast cancer. Researchers systematically reviewed data extracted from 8 studies that examined more than 6,000 subjects.

Researchers observed that women with high circulating levels of levels of α-carotene, β-carotene, lutein, zeaxanthin, lycopene, and total carotenoids had less chances of developing breast cancer. On the other hand, elevated plasma concentrations of β-Cryptoxanthin did not affect breast cancer risk in this study. The findings of this study add to the existing body of evidence that increasing the concentrations of carotenoids in the blood may confer women with significant protection against breast cancer.

Research Summary Information

  • 2012
  • Eliassen AH, Hendrickson SJ, Brinton LA, Buring JE, Campos H, Dai Q, Dorgan JF, Franke AA, Gao YT, Goodman MT, Hallmans G, Helzlsouer KJ, Hoffman-Bolton J, Hultén K, Sesso HD, Sowell AL, Tamimi RM, Toniolo P, Wilkens LR, Winkvist A, Zeleniuch-Jacquotte A, Zheng W, Hankinson SE.
  • Channing Division of Network Medicine, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA. heather.eliassen@channing.harvard.edu
  • Yes, Free full text of study was found:
  • No. Source of funding disclosure not found
  • No. Potential conflicts disclosure not found
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