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A randomized, 12-year primary-prevention trial of beta carotene supplementation for nonmelanoma skin cancer in the physician's health study.
Regular intake of beta-carotene supplements may have no preventive effect on nonmelanoma skin cancer, including basal and squamous cell carcinoma.
This study investigated the association between supplementation with beta-carotene and the risk of developing first non-melanoma skin cancer, including basal cell carcinoma and squamous cell carcinoma. Researchers administered either placebo or beta-carotene supplements to 22,071 healthy male subjects between the ages of 40-84 years for 12 years. The nonmelanoma skin cancer odds ratio was also estimated in each participant in this study.
Researchers observed that the use of beta-carotene supplements had no effect on the risk of developing first nonmelanoma skin cancer. The results of this study do not support the hypothesis that supplementation with beta-carotene may protect individuals against nonmelanoma skin cancer.
Research Summary Information
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2000
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Frieling UM, Schaumberg DA, Kupper TS, Muntwyler J, Hennekens CH.
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Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA.
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Yes, Free full text of study was found:
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No. Source of funding disclosure not found
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No. Potential conflicts disclosure not found
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