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Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Indulging in foods rich in vitamin C may boost an individual's defense against oral, pharyngeal, and laryngeal cancer.

​This meta-analysis investigated the hypothesis that higher intake of foods packed with vitamin C can reduce the risk of occurrence of cancer in the head and neck. Researchers collated dietary and medical data drawn out of 10 studies. 

Researchers found an inverse association between increase in the frequency of consumption of vitamin C-containing foods and the onset of oral, pharyngeal, and laryngeal cancers. Data from this study support the hypothesis that regular ingestion of vitamin C from food sources can substantially decrease the incidence of cancers occurring in the head and neck region, such as oral, laryngeal, and pharyngeal cancer.

Research Summary Information

  • 2015
  • Edefonti V, Hashibe M, Parpinel M, Turati F, Serraino D, Matsuo K, Olshan AF, Zevallos JP, Winn DM, Moysich K, Zhang ZF, Morgenstern H, Levi F, Kelsey K, McClean M, Bosetti C, Galeone C, Schantz S, Yu GP, Boffetta P, Amy Lee YC, Chuang SC, La Vecchia C, Decarli A.
  • Dipartimento di Scienze Cliche e di Comunità Sezione Di Statistica Medica E Biometria "Giulio A. Maccacaro,", Università degli Studi di Milano, Milan, Italy. Division of Public Health, Department of Family and Preventive Medicine and Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA. Institute of Hygiene and Epidemiology, Department of Medical and Biological Sciences, University of Udine, Udine, Italy. Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri,", Milan, Italy. S.C., Statistica Medica, Biometria e Bioinformatica, Fondazione IRCSS Istituto Nazionale Tumori di Milano, Milan, Italy. Unit of Epidemiology and Biostatistics, CRO Aviano National Cancer Institute, IRCCS, Aviano, Italy. Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Kyushu, Japan. Department of Epidemiology, Gillings School of Global Public Health, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA. Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC. Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD. Department of Cancer Prevention and Control and Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY. Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA. Department of Epidemiology and Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA. Cancer Epidemiology Unit, Institute for Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland. Department of Pathology and Laboratory Medicine and Department of Epidemiology, Brown University, Providence, RI. Department of Environmental Health, Boston University School of Public Health, Boston, MA. Department of Otolaryngology, New York Eye and Ear Infirmary, New York, NY. Medical Informatics Center, Peking University, Peking, China. Tisch Cancer Institute, Mount Sinai School of Medicine, New York, NY. Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT. Institute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
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