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Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.

Contrary to popular belief, regular intake of folic acid supplements may not prevent the occurrence of adverse cardiovascular events, such as stroke, cardiovascular mortality, and myocardial infarction.

​This study evaluated supplementation with folic acid in relation to the incidence of major cardiovascular events, such as stroke and myocardial infarction. Researchers conducted a meticulous meta-analysis on data obtained from 16 randomized controlled trials. They observed that regular consumption of folic acid supplements exerted no preventive effect on adverse cardiovascular events, such as stroke, myocardial infarction, and death. The results of this study indicate that supplementation with folic acid does not affect the risk of stroke, myocardial infarction, and cardiovascular mortality.

Research Summary Information

  • 2011
  • Zhou YH, Tang JY, Wu MJ, Lu J, Wei X, Qin YY, Wang C, Xu JF, He J.
  • Department of Health Statistics, Second Military Medical University, Shanghai, China.
  • Yes, Free full text of study was found:
  • No. Source of funding disclosure not found
  • No. Potential conflicts disclosure not found
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