Negative effect of a low-carbohydrate, high-protein, high-fat diet on small peripheral artery reactivity in patients with increased cardiovascular risk

A low-carbohydrate, high-protein, high-fat diet reduces arterial wall function in patients with high odds of developing cardiovascular diseases.

This study investigated the effect of low-carbohydrate, high-protein, high-fat diet on small artery reactive hyperemia index (saRHI) –a marker for arterial wall function— in patients with increased cardiovascular risk. 247 patients were placed on a low-carbohydrate, high-protein, and high-fat diet. The saRHI values of all the subjects together with their low carbohydrate diet score (LCDS), biochemical, demographic, anthropometry, and physical examination parameters were recorded.

Researchers found out that patients with low LCDS have higher saRHI values than those with high LCDS. Multivariate analysis showed that subjects having the highest LDCS had a negative coefficient of saRHI. This study provides evidence that low-carbohydrate, high-protein, high-fat diet is linked to reduced small peripheral artery vascular reactivity in patients with high risk of developing of cardiovascular diseases.

Research Summary Information

  • 2012
  • Jordi Merino, Richard Kones, Raimon Ferres, Nuria Plana, Josefa Girona, Gemma Aragones, Daiana Ibarretxe, Mercedes Heras and Luis Masana
  • Vascular Medicine and Metabolism Unit, Lipids and Atherosclerosis Research Unit, Sant Joan University Hospital Institut d'Investigació Sanitària Pere Virgili (IISPV), Faculty of Medicine Universitat Rovira i Virgili, Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders (CIBERDEM), Barcelona, Spain Cardiometabolic Research Institute, 7505 Fannin Street, Suite 210, Houston, TX 77054, USA
  • No, Free full text of study was not found.
  • No source of funding disclosure found
  • No potential conflicts disclosure found
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