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Inverse associations between plasma lycopene and other carotenoids and prostate cancer.

Low prostate cancer risk is associated with high plasma levels of lycopene, lutein, zeaxanthin, and beta-cryptoxanthin.

This research work evaluated the relationship between serum concentrations of carotenoids, retinols, and tocopherols and prostate cancer risk. Using high performance liquid chromatography, researchers measured the blood levels of retinols, tocopherols, and carotenoids, such as lutein, zeaxanthin, lycopene, and beta-cryptoxanthin in 197 male subjects. The prostate cancer odds ratio of each participant in this study was also determined.

The team of investigators observed that subjects with high plasma levels of lycopene, lutein, beta-cryptoxanthin, and zeaxanthin had slim chances of developing prostate cancer. Conversely, high serum concentrations of retinol, beta-carotenes, alpha-carotenes, alpha-tocopherol, and gamma-tocopherol were found to have no significant effect on prostate cancer risk in this study. The results of this study suggest that regular consumption of diets loaded with foods rich in lycopene, lutein, zeaxanthin, and beta-cryptoxanthin may protect men against prostate cancer.

Research Summary Information

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