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Intake of fruit juice and incidence of type 2 diabetes: a systematic review and meta-analysis.

Regular consumers of sugar-sweetened fruit juice may have a high tendency to develop type 2 diabetes.

The purpose of this study was to investigate the correlation between fruit juice intake and type 2 diabetes risk by meta-analysis. Four studies that examined 191,686 subjects and 12,375 cases of type 2 diabetes were included in this meta-analysis.

The team of researchers found out that regular consumption of sugar-sweetened fruit juice increased the odds of developing type 2 diabetes. In contrast, generous intake of 100% natural fruit juice was not associated with increased risk of type 2 diabetes in this study. The results of this study suggest that regular drinking of sugar-sweetened fruit juice may contribute positively to the development of type 2 diabetes.

Research Summary Information

  • 2014
  • Xi B, Li S, Liu Z, Tian H, Yin X, Huai P, Tang W, Zhou D, Steffen LM.
  • Department of Maternal and Child Health, School of Public Health, Shandong University, Jinan, China. Department of Epidemiology and Health Statistics, School of Public Health, Shandong University, Jinan, China. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, United States of America. Department of Endocrinology, Linyi People's Hospital, Linyi, China.
  • Yes, Free full text of study was found:
  • No. Source of funding disclosure not found
  • No. Potential conflicts disclosure not found
Sugar-sweetened and artificially sweetened beverag...
Intramyocellular lipid concentrations are correlat...

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This comment was minimized by the moderator on the site

While this is what I would expect to see, unsweetened fruit juice is what I would consider "processed" and certainly not as beneficial as the whole fruit. I wonder exactly how the body is processing the unsweetened fruit juice differently from the sugar-sweetened fruit juice. Is it just the difference in how easy the sugar is to break down, or is there some other protective factor at play in the unsweetened fruit juice that is reducing the risk.

  Comment was last edited about 4 years ago by Site Admin Marky Yvanovich
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Hello Marky,
Your questions are certainly legitimate. Often with these type of studies it seems like a point is made but not all questions are answered. In this case they compared juices with sugar vs juices that did not have sugar added. My guess is that if they compared juice without sugar to pure water there would be a statistical difference. But, I don't see them being able to realistically do that study. :-) I was not able to tell if the 100% juice had fiber as well. Also, we don't know if the difference could have been that the metabolism of the 100% juice was slower due to fiber content.

  Comment was last edited about 4 years ago by Sean Carney Sean Carney
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Fiber certainly is very important in how our body processes/digests food. Let's just look at two examples: Orange Juice and Sunny Delight.
Orange Juice (one ingredient), total calories in 8oz serving: 112, amount of fiber: 0.4g (not a whole lot)
Sunny Delight (main ingredient, corn syrup), total calories in 8oz serving: 60 calories, amount of fiber: 0g

So, 0.4g might seem like an insignificant amount, but might be playing an important role.

Other things to note. Why is SunnyD half the calories when the main ingredient is corn syrup? Because they also add sucralose and acesulfame potassium, two artificial sweeteners. This stuff also has two potentially dangerous artificial colorings as well. Man, I used to drink this stuff. Amazing how we just assume that if it's in a grocery store, that it must be acceptable to eat or drink. Now, when I go into a grocery store, if you exclude the produce aisle, I would guess that there is less than 1% of the products that are actually health promoting. So sad.

  Marky Yvanovich
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Oh, as a comparison in case anyone is interested. The amount of fiber in 112 calories of whole orange is nearly 12 grams. Nice! Eat those whole oranges!

  Marky Yvanovich
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I love your little analysis. You are right that it is very tricky what goes on in the grocery stores. Buyer beware! :-)

I am going to start a private conversation to introduce you and Ken Thomas who is one of our users that I believe you will love getting to know. He has written quite a few blogs on the site as a member blogger: https://www.drcarney.com/blog/bloggers/blogger/kenscircus?start=30 (I gave you his URL at the end which is his first blog because they really should be read in order. :-)

BTW, if you are interested in being a member blogger I can give you the permissions and also teach you how to use the editor.


  Sean Carney
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