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Increased Risk of Dementia in Patients With Antidepressants: A Meta-Analysis of Observational Studies

The odds of suffering from dementia may be stacked against an individual taking antidepressant pills.

This study evaluated the use of antidepressants in relation to the development of dementia using a meta-analytic approach. Researchers compiled data from 9 published studies that examined over 53,000 persons. 

Researchers noticed that individuals on antidepressants, including medications in the class of selective serotonin re-uptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs), had increased likelihood of suffering from dementia. This study provides further evidence that the use of antidepressant drugs may accelerate the onset of dementia.

Research Summary Information

  • 2018
  • Yao-Chin Wang , Po-An Tai , Tahmina Nasrin Poly, Md Mohaimenul Islam, Hsuan-Chia Yang , Chieh-Chen Wu, Yu-Chuan Jack Li
  • Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. Department of Emergency, Min-Sheng General Hospital, Taoyuan City, Taiwan. International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan. Department of Surgery, School of Medicine, Buddhist Tzu Chi University, Hualien, Taiwan. Department of Dermatology, Wan Fang Hospital, Taipei, Taiwan. TMU Research Center of Cancer Translational Medicine, Taipei, Taiwan.
  • Yes, Free full text of study was found:
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