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Seizure Risk Associated With Antidepressant Treatment Among Patients With Depressive Disorders: A Population-Based Case-Crossover Study

Regular intake of antidepressants may precipitate the onset of seizure in a patient with depression.

​This study explored the relationship between the use of antidepressant drugs to treat depression and the propensity to develop new-onset seizure. Researchers surveyed 10,002 patients with depression taking different classes of antidepressant medications from 2002 to 2012. 

Researchers observed that the likelihood of suffering from new-onset seizure went up among users of antidepressant medications. Evidence from this study reinforce the notion that antidepressants may lower the threshold for seizure to occur in an individual.

Research Summary Information

  • 2017
  • Chi-Shin Wu , Hsin-Yen Liu , Hui-Ju Tsai , Shi-Kai Liu
  • Department of Psychiatry, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. Department of Psychiatry, Far Eastern Memorial Hospital, New Taipei City, Taiwan. Health Science Program, McMaster University, Hamilton, Ontario, Canada. Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Department of Public Health, China Medical University, Taichung, Taiwan. Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, 1001 Queen St West, Toronto, Ontario, Canada M6J 1H4. shi-kai_liu@camh.net. Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
  • No, Free full text of study was not found.
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