By Research Summaries on March 8, 2016
Category: Insulin Resistance

Mechanism of free fatty acid induced insulin resistance in humans.

The inhibitory action of free fatty acids on glucose transport, oxidation, and glycogen synthesis may be responsible for lipid-induced insulin resistance in humans.

This study investigated the mechanism of action of lipid-induced insulin resistance in humans. Researchers measured the skeletal muscle glycogen levels, plasma levels of free fatty acids, and serum glucose-6-phosphate concentrations in nine healthy subjects at intervals of 15 minutes for 6 hours.

They discovered that high plasma concentration of free fatty acids inhibited glucose uptake and increased insulin resistance by cells of the skeletal muscle, therefore increasing the risk of type 2 diabetes development. According to this study, the inhibition of glucose transport followed by a drastic reduction in glycogen synthesis and glucose oxidation mediated the insulin resistance activity of free fatty acids .

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