Fats, inflammation, and insulin resistance: insights to the role of macrophage and T-cell accumulation in adipose tissue.

High fat diets may promote the development insulin resistance and type-2 diabetes.

This study was carried out to determine the role of high fat diets in the promotion of inflammation and insulin resistance in adipose tissues. Researchers reviewed relevant published literatures on the subject.

Researchers observed that high fat diets were associated with adipose tissue inflammation and obesity-induced insulin resistance. Macrophages and cytotoxic T-cells were found to mediate obesity-induced insulin resistance through the action of endotoxins, such as cytokinines IL-Iβ and TNF-α. These endotoxins create a pro-inflammatory environment that promotes insulin resistance in adipose tissues, leading to the development of type 2 diabetes.

The results of this study suggest that low or moderate fat intake could help to diminish adipose tissue inflammation, insulin resistance, and type 2 diabetes risk.