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Ultra-processed food consumption and risk of colorectal cancer precursors: results from 3 prospective cohorts

Habitual intake of ultra-processed foods may give rise to precursors of colorectal cancer, such as adenomas and polyps.

This study examined the link between ultra-processed food (UPF) consumption and the occurrence of precursors of colorectal cancer (CRC), such as adenomas and polyps. Out of the 142,052 men and women whose diets were examined over a 20-year period, 22,122 of them developed colorectal adenomas and serrated lesions during the course of the study. 

Researchers discovered that precursors of colorectal cancer tend to occur at a high rate among lovers of ultra-processed foods. This study concluded that "higher consumption of UPFs is associated with an increased risk of CRC precursors."

Research Summary Information

  • 2023
  • Dong Hang, Lu Wang, Zhe Fang, Mengxi Du, Kai Wang, Xiaosheng He, Neha Khandpur, Sinara L Rossato, Kana Wu, Zhibin Hu, Hongbing Shen, Shuji Ogino, Andrew T Chan, Edward L Giovannucci, Fang Fang Zhang, Mingyang Song
  • Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Gusu School, Nanjing Medical University, Nanjing, China. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Department of Colorectal Surgery, the Six Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil. Center for Epidemiological Studies in Health and Nutrition (NUPENS), Faculty of Public Health, University of São Paulo, Brazil. Institute of Geography, Universidade Federal de Uberlândia, Minas Gerais, Brazil. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. Cancer Immunology Program, Dana-Farber Harvard Cancer Center, Boston, MA, USA. Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Clinical and Translational Epidemiology Unit and Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • No, Free full text of study was not found.
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