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Cigarette smoking as a risk factor for the development of and mortality from hepatocellular carcinoma: An updated systematic review of 81 epidemiological studies.

​A surge in liver cancer development and mortality risk is associated with cigarette smoking.

​This study investigated the connection between cigarette smoking and hepatocellular cancer (HCC) development and mortality risk using a meta-analytic approach. A total of 81 studies were included in this meta-analysis. 

Researchers discovered that cigarette smokers had high tendency to acquire and die from hepatocellular (liver) cancer compared to non-smokers. The authors concluded that "Cigarette smoking increases the incidence and mortality of HCC."

Research Summary Information

  • 2017
  • Abdel-Rahman O, Helbling D, Schöb O, Eltobgy M, Mohamed H, Schmidt J, Giryes A, Mehrabi A, Iype S, John H, Tekbas A, Zidan A, Oweira H.
  • Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Department of Medical Oncology, Gastrointestinal Tumor Center Zurich, Zurich, Switzerland. Surgical Center Zurich, Hirslanden Hospital Zurich, Zurich, Switzerland. Department of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany. Department of Surgery, Cambridge University Hospital, Cambridge, United Kingdom. Department of HPB and Liver Transplantation, Rajhy Liver Hospital, Assiut University, Assiut, Egypt.
  • Yes, Free full text of study was found:
Smoking as an independent risk factor for hepatoce...
A surge in the risk of esophageal cancer is associ...

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