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Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis.

A significant reduction in insulin sensitivity may be found in healthy individuals who consumed caffeine regularly.

​Insulin resistance is the hallmark of type 2 diabetes. This study evaluated the impact dietary intake of caffeine has on insulin sensitivity in healthy persons. Researchers compiled data obtained from 7 randomized control trials (RCTs).

After analysis of the data, researchers discovered that caffeine consumption resulted in significant decrease in insulin sensitivity. This meta-analysis supports the hypothesis that regular dietary exposure to caffeine may put a healthy individual on the path to having insulin resistance.

Research Summary Information

  • 2016
  • Shi X, Xue W, Liang S, Zhao J, Zhang X.
  • Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, No. 43 Daxue Road, 450052, Zhengzhou, People's Republic of China. Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, No. 43 Daxue Road, 450052, Zhengzhou, People's Republic of China. hnmuzj@163.com. Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, No. 43 Daxue Road, 450052, Zhengzhou, People's Republic of China. xiaojianzhang2016@163.com.
  • Yes, Free full text of study was found:
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