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Hydrochlorothiazide use and risk of nonmelanoma skin cancer: A nationwide case-control study from Denmark.

High skin cancer risk is associated with the use of hydrochlorothiazide.

​This study investigated the connection between the intake of the antihypertensive drug hydrochlorothiazide and the tendency of developing skin cancer. Researchers used data extracted from both the Danish Cancer and Prescription Registries. 

Researchers noted that the use of hydrochlorothiazide is associated with the onset of nonmelanoma skin cancer. The findings of this study suggest that regular intake of hydrochlorothiazide may be a contributing factor to the development of skin cancer.

Research Summary Information

  • 2018
  • Pedersen SA, Gaist D, Schmidt SAJ, Hölmich LR, Friis S, Pottegård A.
  • Department of Neurology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, Faculty of Health Sciences, Odense, Denmark; Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark. Department of Neurology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, Faculty of Health Sciences, Odense, Denmark. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. Department of Plastic Surgery, Herlev-Gentofte Hospital, Herlev, Denmark. Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark. Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark. Electronic address: apottegaard@health.sdu.dk.
  • Yes, Free full text of study was found:
Use of Antihypertensive Drugs and Risk of Malignan...

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