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Anti-Hypertensive Medication Use, Soluble Receptor for Glycation End Products and Risk of Pancreatic Cancer in the Women's Health Initiative Study.

Regular use of short-acting calcium channel blockers, such as Nifedipine, Amlodipine, and Verapamil, may facilitate the onset of pancreatic cancer in postmenopausal women.

​This study examined the correlation between the use of antihypertensive drugs and the risk of pancreatic cancer in women. A total of 145,551 women participated in this study and were assessed for their intake of antihypertensive medications and incidence of pancreatic cancer. 

Researchers observed that postmenopausal women who took short-acting calcium channel blockers (CCBs), such as Nifedipine, Amlodipine, and Verapamil for 3 or more years had 107% higher chances of acquiring pancreatic cancer. Evidence from this study show that the use of short-acting calcium channel blockers may fuel the development of pancreatic cancer in postmenopausal women.

Research Summary Information

  • 2018
  • Wang Z, White DL, Hoogeveen R, Chen L, Whitsel EA, Richardson PA, Virani SS, Garcia JM, El-Serag HB, Jiao L.
  • Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. zhenshew@bcm.edu. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. dwhite1@bcm.edu. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. dwhite1@bcm.edu. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. dwhite1@bcm.edu. Texas Medical Center Digestive Disease Center, Houston, TX 77030, USA. dwhite1@bcm.edu. Dan L. Duncan Cancer Center at Baylor College of Medicine, Houston, TX 77030, USA. dwhite1@bcm.edu. Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. dwhite1@bcm.edu. Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. ronh@bcm.edu. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. liangc@bcm.edu. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. liangc@bcm.edu. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. liangc@bcm.edu. Departments of Epidemiology and Medicine, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. eric_whitsel@med.unc.edu. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. peter.richardson2@va.gov. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. peter.richardson2@va.gov. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. virani@bcm.edu. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. virani@bcm.edu. Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. virani@bcm.edu. Geriatric Research Education and Clinical Center (GRECC), Puget Sound Department of Veterans Affairs Medical Center, Seattle, WA 98108, USA. Jg77@uw.edu. Section of Endocrinology, Department of Medicine, University of Washington, Seattle, WA 98195, USA. Jg77@uw.edu. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. hasheme@bcm.edu. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. hasheme@bcm.edu. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. hasheme@bcm.edu. Texas Medical Center Digestive Disease Center, Houston, TX 77030, USA. hasheme@bcm.edu. Dan L. Duncan Cancer Center at Baylor College of Medicine, Houston, TX 77030, USA. hasheme@bcm.edu. 25 Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. jiao@bcm.edu. 26 Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. jiao@bcm.edu. 27 Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. jiao@bcm.edu. 28 Texas Medical Center Digestive Disease Center, Houston, TX 77030, USA. jiao@bcm.edu. 29 Dan L. Duncan Cancer Center at Baylor College of Medicine, Houston, TX 77030, USA. jiao@bcm.edu. 30 Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. jiao@bcm.edu.
  • Yes, Free full text of study was found:
Association Between the Use of Thiazide Diuretics ...

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