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Anti-Hypertensive Medication Use, Soluble Receptor for Glycation End Products and Risk of Pancreatic Cancer in the Women's Health Initiative Study.
Regular use of short-acting calcium channel blockers, such as Nifedipine, Amlodipine, and Verapamil, may facilitate the onset of pancreatic cancer in postmenopausal women.
This study examined the correlation between the use of antihypertensive drugs and the risk of pancreatic cancer in women. A total of 145,551 women participated in this study and were assessed for their intake of antihypertensive medications and incidence of pancreatic cancer.
Researchers observed that postmenopausal women who took short-acting calcium channel blockers (CCBs), such as Nifedipine, Amlodipine, and Verapamil for 3 or more years had 107% higher chances of acquiring pancreatic cancer. Evidence from this study show that the use of short-acting calcium channel blockers may fuel the development of pancreatic cancer in postmenopausal women.
Research Summary Information
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2018
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Wang Z, White DL, Hoogeveen R, Chen L, Whitsel EA, Richardson PA, Virani SS, Garcia JM, El-Serag HB, Jiao L.
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Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. zhenshew@bcm.edu. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. dwhite1@bcm.edu. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. dwhite1@bcm.edu. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. dwhite1@bcm.edu. Texas Medical Center Digestive Disease Center, Houston, TX 77030, USA. dwhite1@bcm.edu. Dan L. Duncan Cancer Center at Baylor College of Medicine, Houston, TX 77030, USA. dwhite1@bcm.edu. Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. dwhite1@bcm.edu. Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. ronh@bcm.edu. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. liangc@bcm.edu. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. liangc@bcm.edu. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. liangc@bcm.edu. Departments of Epidemiology and Medicine, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. eric_whitsel@med.unc.edu. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. peter.richardson2@va.gov. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. peter.richardson2@va.gov. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. virani@bcm.edu. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. virani@bcm.edu. Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. virani@bcm.edu. Geriatric Research Education and Clinical Center (GRECC), Puget Sound Department of Veterans Affairs Medical Center, Seattle, WA 98108, USA. Jg77@uw.edu. Section of Endocrinology, Department of Medicine, University of Washington, Seattle, WA 98195, USA. Jg77@uw.edu. Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. hasheme@bcm.edu. Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. hasheme@bcm.edu. Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. hasheme@bcm.edu. Texas Medical Center Digestive Disease Center, Houston, TX 77030, USA. hasheme@bcm.edu. Dan L. Duncan Cancer Center at Baylor College of Medicine, Houston, TX 77030, USA. hasheme@bcm.edu. 25 Section of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. jiao@bcm.edu. 26 Center for Innovations in Quality, Effectiveness and Safety (IQuESt), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. jiao@bcm.edu. 27 Section of Health Services Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA. jiao@bcm.edu. 28 Texas Medical Center Digestive Disease Center, Houston, TX 77030, USA. jiao@bcm.edu. 29 Dan L. Duncan Cancer Center at Baylor College of Medicine, Houston, TX 77030, USA. jiao@bcm.edu. 30 Center for Translational Research on Inflammatory Diseases (CTRID), Michael E. DeBakey VA Medical Center, Houston, TX 77030, USA. jiao@bcm.edu.
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