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Tricyclic Antidepressant Use and Risk of Fractures: A Meta-Analysis of Cohort and Case-Control Studies

Users of medications in the class of tricyclic antidepressants (TCA) may be at risk of suffering from fracture.

 This meta-analysis evaluated studies associating increased risk of fracture with the use of antidepressant drugs belonging to the tricyclic antidepressant (TCA) class. A total of 12 studies were included in this meta-analysis. 

Researchers noted that frequent usage of tricyclic antidepressants correlated with heightened risk of fracture. This study concluded that treatment with tricyclic antidepressants may promote the occurrence of fracture.

Research Summary Information

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