Selective Serotonin Reuptake Inhibiting Antidepressants Are Associated With an Increased Risk of Nonvertebral Fractures

Nonvertebral fracture is highly likely to occur in individuals taking selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs).

This study looked at the connection between the use of antidepressants and the likelihood of experiencing fracture in a non-vertebral bone. The study population included 7,983 Dutch men and women aged 55 years and above recruited from the Rotterdam Study. 

Researchers observed that the tendency to suffer from nonvertebral fracture increased with the use of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs). Evidence from this study indicate that individuals treated with drugs in the family of selective serotonin reuptake inhibitors and tricyclic antidepressants may be highly prone to fracturing their nonvertebral bones.