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Zolpidem and the risk of Parkinson's disease: a nationwide population-based study.

The use of the sleeping pill zolpidem may increase an individual's chances of having Parkinson's disease.

​Zolpidem is one of the most commonly prescribed sleeping pills worldwide. This study analyzed the relationship between the use of zolpidem and Parkison's disease (PD) risk. Researchers followed more than 100,000 Taiwanese men and women for 5 years, monitoring their drug prescription and health records. 

Researchers noticed that participants diagnosed with sleep disturbance who were placed on zolpidem medication were far more likely to develop Parkinson's disease than non-users of this sleeping pill. The study concluded that "among patients with sleep disturbance, zolpidem use increased the risk of PD after 5 years of follow-up."

Research Summary Information

  • 2014
  • Yang YW, Hsieh TF, Yu CH, Huang YS, Lee CC, Tsai TH.
  • Department of Neurology, China Medical University Hospital and School of Medicine, China Medical University, Taichung, Taiwan. Department of Urology, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan; School of Medicine, Tzu Chi University, Hualian, Taiwan. Department of Medical Research, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Ming-Sheng Road, Dalin Town, Chiayi 622, Taiwan, ROC. Division of Neurology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Ming-Sheng Road, Dalin Town, Chiayi 622, Taiwan, ROC. Electronic address: solomons1117@yahoo.com.tw. School of Medicine, Tzu Chi University, Hualian, Taiwan; Department of Otolaryngology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Ming-Sheng Road, Dalin Town, Chiayi 622, Taiwan, ROC; Department of Education, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Ming-Sheng Road, Dalin Town, Chiayi 622, Taiwan, ROC. Electronic address: hematcd@hotmail.com. Department of Psychiatry, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Ming-Sheng Road, Dalin Town, Chiayi 622, Taiwan, ROC. Electronic address: tsaitsunghuang@hotmail.com.
  • No, Free full text of study was not found.
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