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Mechanism of free fatty acid induced insulin resistance in humans.
The inhibitory action of free fatty acids on glucose transport, oxidation, and glycogen synthesis may be responsible for lipid-induced insulin resistance in humans.
This study investigated the mechanism of action of lipid-induced insulin resistance in humans. Researchers measured the skeletal muscle glycogen levels, plasma levels of free fatty acids, and serum glucose-6-phosphate concentrations in nine healthy subjects at intervals of 15 minutes for 6 hours.
They discovered that high plasma concentration of free fatty acids inhibited glucose uptake and increased insulin resistance by cells of the skeletal muscle, therefore increasing the risk of type 2 diabetes development. According to this study, the inhibition of glucose transport followed by a drastic reduction in glycogen synthesis and glucose oxidation mediated the insulin resistance activity of free fatty acids .
Research Summary Information
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1996
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M Roden, T B Price, G Perseghin, K F Petersen, D L Rothman, G W Cline, G I Shulman
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Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
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Yes, Free full text of study was found:
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