​A surge in the risk of penile cancer is associated with tobacco chewing, smoking, and snuffing.

This study investigated the hypothesis that tobacco use increases the risk of penile cancer. Researchers studied the tobacco usage habits of 503 subjects and compared their odds of developing cancer of the penis.

Researchers found a high incidence of squamous cell carcinoma of the penis among subjects who smoke, chew, or inhale (snuff) tobacco. The findings of this study support the hypothesis that the use of tobacco may contribute positively to the development of penile cancer.