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A milk protein, casein, as a proliferation promoting factor in prostate cancer cells
Milk protein, casein, may promote the proliferation of prostate cancer cells, such as PC3 and LNCaP.
This study investigated the effect of the milk protein, casein, on the proliferation of prostate cancer cells. Different concentrations (0.1 and 1 mg/mL) of α-casein and total casein obtained from bovine milk were used to treat prostate cancer cells (LNCaP and PC3), lung cancer cells (A459), stomach cancer cells (SNU484), breast cancer cells (MCF7), immortalized human embryonic kidney cells (HEK293), and immortalized normal prostate cells (RWPE1) in a serum free media for 72 hours. Using an MTT assay, researchers examined the proliferation of each line.
Researchers discovered that α-casein and total casein increased the number of prostate cancer cells, but they had no effect on the proliferations of lung, breast, stomach, immortalized normal prostate, and immortalized human embryonic kidney cancerous cells. This study provides strong evidence that high consumption of milk may lead to increase in cancerous cells in prostate cancer patients.
Research Summary Information
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2014
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Park SW, Kim JW, Kim YS, Lee SJ, Lee SG, Chung MK
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Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea. ; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea Institute for Medical Sciences, Ajou University School of Medicine, Suwon, Korea Genitourinary Cancer Branch, National Cancer Center, Goyang, Korea Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea
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No, Free full text of study was not found.
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No. Source of funding disclosure not found
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No. Potential conflicts disclosure not found
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