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Serotonergic antidepressant use and the risk of fracture: a population-based nested case-control study.

Frequent usage of serotonergic antidepressants may heighten an individual's risk of experiencing fractures.

​This study examined the use of serotonergic antidepressants in relation to the occurrence of fracture. Researchers compared the rate of occurrence of fracture between 8,250 patients on antidepressants and 33,000 healthy subjects. 

Researchers found a high prevalence of fracture among users of serotonergic antidepressants compared to non-users of these medications. Evidence from this study show that regular intake of serotonergic antidepressants is tied to a high risk of fracture.

Research Summary Information

  • 2016
  • Wang CY, Fu SH, Wang CL, Chen PJ, Wu FL, Hsiao FY.
  • Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, 2F.-220, No. 33, Linsen S. Rd., Zhongzheng District, Taipei, 100, Taiwan. Department of Orthopedics, National Taiwan University Hospital, Taipei, Taiwan. Department of Psychiatry, Chang Gung Memorial Hospital, Taipei, Taiwan. Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, 2F.-220, No. 33, Linsen S. Rd., Zhongzheng District, Taipei, 100, Taiwan. flwu@ntu.edu.tw. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. flwu@ntu.edu.tw. Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan. flwu@ntu.edu.tw. Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, 2F.-220, No. 33, Linsen S. Rd., Zhongzheng District, Taipei, 100, Taiwan. fyshsiao@ntu.edu.tw. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. fyshsiao@ntu.edu.tw. Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan. fyshsiao@ntu.edu.tw.
  • No, Free full text of study was not found.
Selective serotonin reuptake inhibitor (SSRI) use ...

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