Prolonged fasting reduces IGF-1/PKA to promote hematopoietic stem cell based regeneration and reverse immunosuppresion.

Prolonged fasting can protect hematopoietic stem cells from aging and cancer chemotherapy.

This research work was carried out to determine the effect of prolonged fasting on age-induced and chemotherapy-induced damage to hematopoietic stem cells (HSCs). Mice and humans were studied for this research work.

Researchers found out that multiple cycles of prolonged fasting decreased the concentrations of insulin-like growth factor (IGF-1) and the activity of protein kinase A (PKA) .Diminished IGLF levels and PKA activity were observed to activate signal transduction in long-term hematopoietic stem cells (LT-HSCs) that promoted the rejuvenation of old and damaged stem cells. The findings of this study show that prolonged fasting can reverse immunosuppression and immunosenescence (loss of HSCs) by reducing the concentrations and activity of IGF-1 and PKA.

Research Summary Information

  • 2014
  • Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD.
  • Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA. Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, 1425 San Pablo Street, Los Angeles, CA 90033, USA. Saban Research Institute, Division of Urology, Children's Hospital Los Angeles, University of Southern California, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA. Department of Medical Biotechnology and Forensics, University of Palermo, via Divisi 83, 90133 Palermo, Italy. Translational Oncology Program, Kenneth J. Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA. Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, 228 Irvine Hall, Athens, OH 45701, USA. Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, 1425 San Pablo Street, Los Angeles, CA 90033, USA; IFOM, FIRC Institute of Molecular Oncology, Via Adamello, 16, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.
  • Yes, Free full text of study was found:
  • Source of funding disclosure found
  • This study was funded in part by NIH/NIA grants AG20642, AG025135 and P01 AG034906.
  • No potential conflicts disclosure found
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