Diet rapidly and reproducibly alters the human gut microbe.

High intake of animal-based diets may increase an individual’s susceptibility to inflammatory bowel disease.

This study investigated the correlation between diets and the types of microbes found in the human gut. Using validated dietary questionnaires, researchers examined the diets of all the subjects. The gut microbial population of each subject was also assessed.

Researchers observed an abundance of bile-tolerant microbes, such as alistipes, Bilophila wadsworthia, and bacteroides, and a decreased number of plant polysaccharide-metabolizing microbes, such as roseburia, Eubacterium rectale, and Rruminococcus bromii in frequent consumers of animal-based diets. Increased activity of Bilophila wadsworthia was found to elevate the risk of developing inflammatory bowel disease in this study. The findings of this study support the theory that animal-based diets may promote the development of inflammatory bowel disease.

Research Summary Information

  • 2014
  • David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ.
  • 1] FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA [2] Society of Fellows, Harvard University, Cambridge, Massachusetts 02138, USA [3] Molecular Genetics & Microbiology and Institute for Genome Sciences & Policy, Duke University, Durham, North Carolina 27708, USA. FAS Center for Systems Biology, Harvard University, Cambridge, Massachusetts 02138, USA. Division of Endocrinology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA. Department of Bioengineering & Therapeutic Sciences and the California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California 94158, USA.
  • Yes, Free full text of study was found:
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