A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan.

Diets that mimic prolonged fasting (FMD) may enhance cognitive function, improve health profile, and increase longevity.

This study investigated the role of diets that mimic fasting (FMD) in the promotion of multi-system regeneration, improved cognitive function, and increased lifespan. Researchers examined data from prolonged fasting pilot clinical trials and studies performed on mice and yeast.

Researchers discovered that prolonged fasting mimetics diminished cancer, aging, diabetes, and cardiovascular disease risk factors in humans. An alternating cycle of prolonged fasting and nutrient-rich medium was found to increase the lifespan of yeasts irrespective of pro-longevity genes. This study suggested that prolonged fasting-mimicing diets stimulate stem cell regeneration, extend longevity, rejuvenate the immune system, decrease cancer risk, and improve cognitive function in mice. These results support the view that prolonged fasting mimetics may help to improve health profile and increase lifespan.

Research Summary Information

  • 2015
  • Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD.
  • Longevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA. GOFARR Laboratory, Children's Hospital Los Angeles, Division of Urology, Saban Research Institute, University of Southern California, Los Angeles, CA 90089, USA. Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Institute for Liver and Digestive Health, Division of Medicine, University College London, Royal Free Hospital, London NW3 2PF, UK. Department of Pathobiology and Medical Biotechnology, University of Palermo, 90100 Palermo, Italy. Global Medicine Program, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Department of Clinical and Biological Sciences, University of Torino, 10100 Torino, Italy. Department of Internal Medicine, University of Genova, 16146 Genova, Italy. Department of Pathology, Barshop Institute, University of Texas Health Science Center, San Antonio, TX 78229, USA. Buck Institute for Research on Aging, Novato, CA 94945, USA. Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA. Longevity Institute, School of Gerontology, and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, 20139 Milano, Italy. Electronic address: vlongo@usc.edu.
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